§ · CORPUS COVERAGE

Coverage

The regulatory corpus Preclari draws on: every source currently onboarded, every source being added next, and the directions we will extend into as customer engagements require. If your jurisdiction or domain isn't listed here, we will onboard it for your engagement. Public jurisdiction additions enter the shared corpus snapshot once onboarded. Your workflow data does not — see retention for what's stored and for how long.

Curated. Every source hand-reviewed. No crawling.

Onboarded

in the corpus today

FDA

Data Integrity and Compliance With Drug CGMP: Questions and Answers (Guidance for Industry)

US · retrieved 2026-05-17 · sha256:1b5074c592ed…

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/data-integrity-and-compliance-drug-cgmp-questions-and-answers

Part 11, Electronic Records; Electronic Signatures — Scope and Application (Guidance for Industry)

US · retrieved 2026-05-17 · sha256:306013031df6…

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/part-11-electronic-records-electronic-signatures-scope-and-application

EudraLex

EudraLex Volume 4 — EU Guidelines for Good Manufacturing Practice — Annex 11: Computerised Systems

EU · retrieved 2026-05-17 · sha256:8ec11211ba33…

https://health.ec.europa.eu/system/files/2016-11/annex11_01-2011_en_0.pdf

EudraLex Volume 4 — EU Guidelines for Good Manufacturing Practice — Annex 15: Qualification and Validation

EU · retrieved 2026-05-20 · sha256:1c3dbbbdf058…

https://health.ec.europa.eu/document/download/7c6c5b3c-4902-46ea-b7ab-7608682fb68d_en?filename=2015-10_annex15.pdf

EudraLex Volume 4 — EU Guidelines for Good Manufacturing Practice — Chapter 1: Pharmaceutical Quality System

EU · retrieved 2026-05-17 · sha256:11e87c3246ab…

https://health.ec.europa.eu/system/files/2016-11/vol4-chap1_2013-01_en_0.pdf

EudraLex Volume 4 — EU Guidelines for Good Manufacturing Practice — Chapter 7: Outsourced Activities

EU · retrieved 2026-05-17 · sha256:5db9b63e58f6…

https://health.ec.europa.eu/document/download/58b5106a-cf6f-4352-9dca-1caf5d27d97e_en?filename=vol4-chap7_2012-06_en.pdf

ICH

ICH Q10 — Pharmaceutical Quality System

ICH · retrieved 2026-05-17 · sha256:396b99197692…

https://database.ich.org/sites/default/files/Q10%20Guideline.pdf

ICH Q9(R1) — Quality Risk Management

ICH · retrieved 2026-05-17 · sha256:007a97272eec…

https://database.ich.org/sites/default/files/ICH_Q9%28R1%29_Guideline_Step4_2023_0126_0.pdf

WHO

WHO Technical Report Series 1033, Annex 4 — Guideline on Data Integrity

WHO · retrieved 2026-05-17 · sha256:7340cd60912b…

https://cdn.who.int/media/docs/default-source/medicines/norms-and-standards/guidelines/inspections/trs1033-annex4-guideline-on-data-integrity.pdf

MHRA

MHRA 'GXP' Data Integrity Guidance and Definitions (Revision 1, March 2018)

UK · retrieved 2026-05-17 · sha256:e05dda11a933…

https://assets.publishing.service.gov.uk/media/5aa2b9ede5274a3e391e37f3/MHRA_GxP_data_integrity_guide_March_edited_Final.pdf

PIC/S

PIC/S PE 009-17 — Guide to Good Manufacturing Practice for Medicinal Products, Part I, Chapter 1: Pharmaceutical Quality System

PICS · retrieved 2026-05-17 · sha256:7deb95a770fa…

https://picscheme.org/docview/6606

Swissmedic

Swissmedic MepV — Medizinprodukteverordnung SR 812.213 (Swiss Medical Devices Ordinance) — Post-market surveillance, vigilance, and PRRC obligations

CH · retrieved 2026-05-25 · sha256:2800253afc26…

https://www.fedlex.admin.ch/eli/cc/2020/552/de

European Commission

EU MDR — Regulation (EU) 2017/745 on medical devices — Articles 10, 15, 83–87, Annex I, Annex III

EU · retrieved 2026-05-25 · sha256:040e3faa1aa0…

https://eur-lex.europa.eu/legal-content/EN/TXT/HTML/?uri=CELEX:32017R0745

EU IVDR — Regulation (EU) 2017/746 on in vitro diagnostic medical devices — Articles 10, 15, 78–82, Annex I, Annex III

EU · retrieved 2026-05-25 · sha256:151022a895db…

https://eur-lex.europa.eu/legal-content/EN/TXT/HTML/?uri=CELEX:32017R0746

IMDRF

IMDRF — Software as a Medical Device (SaMD) Framework: Key Definitions (N10), Risk Categorization (N12), Clinical Evaluation (N41)

International · retrieved 2026-05-25 · sha256:f3e1c7d076db…

https://www.imdrf.org/working-groups/software-medical-device-samd

ISO / FDA

ISO 13485:2016 — Medical devices — Quality management systems — Requirements for regulatory purposes (FDA-incorporated version via 21 CFR Part 820 QMSR, 89 FR 7496)

International · retrieved 2026-05-25 · sha256:1d8698e1ffc6…

https://www.ecfr.gov/current/title-21/chapter-I/subchapter-H/part-820

Planned next

active onboarding

Swissmedic guidance on computerised systems in GMP

Swissmedic · CH

Unlocks: Swiss manufacturing AI workflows; aligns Preclari output with Swiss inspection expectations under PIC/S Annex 11

Roadmap — sources & documents

ordered by demand signal

EU GMP deepening (validation + QP release)

EudraLex Volume 4, Annex 15 — Qualification and Validation

EudraLex · EU

Unlocks: CSV-heavy and validation-touching AI workflows

EudraLex Volume 4, Annex 16 — Certification by a Qualified Person and Batch Release

EudraLex · EU

Unlocks: QP decision-support AI

ICH Q7 — Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients

ICH · ICH

Unlocks: API manufacturing AI workflows (deviation, OOS, change control)

FDA Draft Guidance — Considerations for the Use of Artificial Intelligence and Machine Learning in Drug Manufacturing AI-specific context

FDA · US

Unlocks: AI-specific GMP context for US workflows

EMA Reflection Paper on the Use of Artificial Intelligence in the Lifecycle of Medicinal Products AI-specific context

EMA · EU

Unlocks: AI-specific EU context across the medicinal product lifecycle

Medtech (EU MDR + US FDA)

EU MDR — Regulation (EU) 2017/745 on medical devices — Articles 10 (manufacturer obligations), 83-87 (post-market surveillance and vigilance), Annex I (general safety and performance requirements), Annex II (technical documentation), Annex III (post-market surveillance plan), Annex XIV (clinical evaluation)

European Commission · EU

Unlocks: Medical device AI/ML workflows: risk-based validation, post-market surveillance, complaint handling, PRRC sign-off paths

US FDA — 21 CFR Part 803, Medical Device Reporting

FDA · US

Unlocks: US adverse-event reporting workflows for AI-enabled medical devices

US FDA 21 CFR Part 820, the Quality Management System Regulation (QMSR); the QMSR final rule (89 FR 7496) amends Part 820 to incorporate ISO 13485:2016 by reference, applying from 2 February 2026

FDA · US

Unlocks: US medical device AI/ML quality system workflows under the QMSR (21 CFR Part 820 as amended in 2024 to incorporate ISO 13485:2016 by reference; compliance from 2 February 2026)

MHRA Medical Devices Guidance — UK CA marking path (post-Brexit)

MHRA · UK

Unlocks: UK CA marking decisions for AI-enabled medical devices

IMDRF — global medical device harmonisation framework (SaMD, MDSAP)

IMDRF · International

Unlocks: Software as a Medical Device classification and audit-trail patterns aligned with global harmonisation guidance

EU IVDR — Regulation (EU) 2017/746 on in-vitro diagnostic medical devices

European Commission · EU

Unlocks: In-vitro diagnostic AI workflows; structurally similar to MDR with IVD-specific performance and clinical evidence requirements

EU AI Act — high-risk systems

EU AI Act — Regulation (EU) 2024/1689 — Article 6 (high-risk classification), Article 9 (risk management), Article 10 (data governance), Article 11 + Annex IV (technical documentation), Article 12 (logging), Article 13 (transparency), Article 14 (human oversight), Article 26 (deployer obligations), Article 72 (post-market monitoring), Annex III (high-risk categories) AI-specific context

European Commission · EU

Unlocks: Audit-defensible preflight for any Annex III high-risk AI system — produces an Article 6 + Annex IV-aware PIF artifact ahead of the August 2026 enforcement deadline

EBA Guidelines on loan origination and monitoring (EBA/GL/2020/06) — § 4.3.4 (automated models in credit decisions)

EBA · EU

Unlocks: AI-assisted credit decision workflows; intersects with AI Act Annex III §5(b)

EBA Report — Machine Learning for IRB credit risk models (EBA/REP/2023/28)

EBA · EU

Unlocks: Machine learning in internal-ratings-based credit risk modelling, with model-risk governance and explainability requirements

ECB Guide to Internal Models — model governance expectations for SSM-supervised institutions

ECB · EU

Unlocks: Internal model governance expectations for euro-area supervised banks deploying AI in regulated functions

EU DORA — Regulation (EU) 2022/2554 on digital operational resilience for the financial sector

European Commission · EU

Unlocks: Operational resilience requirements for AI systems in financial services; intersects with AI Act on system reliability, third-party risk, and incident reporting (applies from January 2025)

NIST AI Risk Management Framework — parallel US framing (less prescriptive than the EU AI Act; complement, not substitute) AI-specific context

NIST · US

Unlocks: US-side AI risk management framing for buyers also subject to EU AI Act; gives a single PIF that addresses both regimes

Roadmap — jurisdictions & domains

onboarded for your engagement

Japan — PMDA

Prioritised as the first non-EU/US jurisdiction; many global pharma AI projects expand JP after EU+US.

Pharmaceuticals and Medical Devices Agency guidance not yet onboarded; translation and structural alignment required.

We onboard for: Your workflow touches Japanese market authorisations or PMDA-inspected sites.

China — NMPA

National Medical Products Administration guidance not yet onboarded; corpus requires NMPA-specific document curation.

We onboard for: Your workflow operates in or imports to mainland China and is regulated by NMPA.

India — CDSCO

Central Drugs Standard Control Organisation guidance not yet onboarded.

We onboard for: Your workflow involves CDSCO-regulated manufacturing or distribution.

Brazil — ANVISA

Agência Nacional de Vigilância Sanitária guidance not yet onboarded.

We onboard for: Your workflow operates under ANVISA jurisdiction.

Korea — MFDS

Ministry of Food and Drug Safety guidance not yet onboarded.

We onboard for: Your workflow involves Korean market authorisation or MFDS-inspected sites.

GCP and GLP

The first v0.1 wedge is GMP-adjacent workflows. Clinical (GCP) and laboratory (GLP) preflight require their own corpus and reasoning patterns and are deferred to a later release.

We onboard for: Your workflow is clinical-research-facing (GCP) or non-clinical laboratory (GLP).

Veterinary medicines

Veterinary GMP and EMA/CVMP veterinary medicines guidance are not yet onboarded. They differ enough from human-pharma GMP to warrant a separate corpus.

We onboard for: Your workflow is veterinary-pharma rather than human-pharma.

Switzerland — IvDV (In-vitro-Diagnostika-Verordnung, SR 812.219)

Swiss IVD ordinance (Switzerland's parallel to EU IVDR 2017/746) not yet onboarded. MepV (Swiss MDR parallel, SR 812.213) is covered. IvDV requires separate extraction under the same verbatim gate.

We onboard for: Your workflow involves Swiss in-vitro diagnostic devices regulated under IvDV.

IMDRF — MDSAP audit criteria

Medical Device Single Audit Program (MDSAP) audit approach and task descriptions (IMDRF/MDSAP WG/N9 and related documents) not yet extracted. The imdrf-samd-mdsap corpus entry covers SaMD frameworks only. MDSAP covers manufacturers in AU/BR/CA/JP/US.

We onboard for: Your workflow involves MDSAP audit readiness or single-audit participation.

Need a jurisdiction or domain not yet on this page?

Onboarding is driven by real engagements. If your workflow touches a jurisdiction, regulator, or GxP domain that isn't visible here yet, : we will onboard it as part of getting you onto Preclari.